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The concomitant administration of the protease inhibitor ritonavir substantially increases serum concentrations of sildenafil (11-fold increase in AUC). If VIAGRA is prescribed to patients taking ritonavir, caution should be used. Data from subjects exposed to high systemic levels of sildenafil are limited. Decreased blood pressure, syncope, and prolonged erection were reported in some healthy volunteers exposed to high doses of sildenafil (200-800 mg). To decrease the chance of adverse reactions in patients taking ritonavir, a decrease in sildenafil dosage is recommended [see DOSAGE AND ADMINISTRATION, DRUG INTERACTIONS, and CLINICAL PHARMACOLOGY]. Combination With Other PDE5 Inhibitors Or Other Erectile Dysfunction Therapies .
Therefore, age > 65, hepatic impairment and severe renal impairment are associated with increased plasma levels of sildenafil. A starting oral dose of 25 mg should be considered in those patients [see DOSAGE AND ADMINISTRATION].
Workforce MyBAUSPatient Information Leaflets PatientsCOVID-19: Information for Patients Find a Surgeon What Is Urology?
Benign Prostatic Hyperplasia/BPH, Bladder Cancer, Erectile Dysfunction, General Urology, Penile Implant, Robotic surgery, Robotic Surgery for Prostate and Kidney Cancers, UroLift, Vasectomy
Sildenafil is the generic version of Viagra, the first-line medication offered by many doctors because it’s been on the market longest and its side effects and drug interactions are well known. Sildenafil works exactly as Viagra does and can cause the same side effects, including dizziness, nausea, rash, pain in the arms or legs, and abnormal vision.
As much as he wants to know more about male enhancement products like penis pills, penis pumps, sex dolls, and pocket pussies, there’s not a lot of worthy information on the web. It’s like such topics are taboo or just no one wants to discuss it openly.
Erectile dysfunction is very common and so are the misconceptions surrounding it. For instance, erectile dysfunction is not necessarily a result of aging and is often the result of an underlying physical health problem.
Dietary supplements for erectile dysfunction: A natural treatment for ED?, Mayo Clinic.Erectile Dysfunction: Diagnosis and Treatment, Mayo Clinic.5 Ways to Overcome Erectile Dysfunction, Harvard Medical School.Erectile Dysfunction, Cleveland Clinic.
Matthew was concerned he might have a medical problem, so Leah encouraged him to get help. Last fall he made an appointment with Charles Walker, MD, a urologist who specializes in ED who was then at Yale Medicine. ED is difficulty getting and keeping an erection. The visit involved an examination as well as some counseling, which surprised Matthew. “I was able to open up and really talk about the issues,” he says.
Erectile dysfunction can be a difficult problem to discuss with your partner or even your doctor. However, it needn't be because erectile dysfunction, which causes sexual performance issues for men, is a very common and highly treatable condition.
Drugwatch.com writers follow rigorous sourcing guidelines and cite only trustworthy sources of information, including peer-reviewed journals, court records, academic organizations, highly regarded nonprofit organizations, government reports and interviews with qualified experts. Review our editorial policy to learn more about our process for producing accurate, current and balanced content. Berman, L. (2014, June 25). The truth about erectile dysfunction. Retrieved from: https://www.foxnews.com/health/the-truth-about-erectile-dysfunction Brophy Marcus, M. (2016, March 10). First generic version of Viagra approved by FDA. Retrieved from: https://www.cbsnews.com/news/first-generic-drug-for-viagra-called-sildenafil-citrate-approved-by-fda/ FDA. (2012, August 30). FDA Drug Safety Communication: FDA recommends against use of Revatio (sildenafil) in children with pulmonary hypertension. Retrieved from: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-recommends-against-use-revatio-sildenafil-children-pulmonary FDA. (2014, March 31). FDA Drug Safety Communication: FDA clarifies Warning about Pediatric Use of Revatio (sildenafil) for Pulmonary Arterial Hypertension. Retrieved from: https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-clarifies-warning-about-pediatric-use-revatio-sildenafil-pulmonary FDA. (2018). Full Prescribing Information: Revatio (sildenafil). Retrieved from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021845s018lbl.pdf FDA. (2017). Viagra – sildenafil citrate tablet, film coated: Full Prescribing Information. Retrieved from: http://labeling.pfizer.com/ShowLabeling.aspx?id=652 Brigham Health. (2020). Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION). Retrieved from: https://www.brighamandwomens.org/neurology/neuro-ophthalmology/non-arteritic-anterior-ischemic-optic-neuropathy Heid, M. (2014, October 28). The Truth about Erectile Dysfunction. Retrieved from: https://www.menshealth.com/health/a19521004/rising-erectile-dysfunction-rates/ History.com, A&E Television Networks, LLC. (2019, July 28). 1998: FDA approves Viagra. Retrieved from: http://www.history.com/this-day-in-history/fda-approves-viagra Li, W., Qureshi, A. A., Robinson, K. C., et al. (2014). Sildenafil Use and Increased Risk of Incident Melanoma in US Men: A Prospective Cohort Study. Retrieved from: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/1857095 MedlinePlus, NIH. (2018, January 15). Sildenafil. Retrieved from: https://medlineplus.gov/druginfo/meds/a699015.html MedlinePlus, NIH. (2016, August 24). Sexual Problems in Men. Retrieved from: https://medlineplus.gov/sexualproblemsinmen.html MedlinePlus, NIH. (2017, January 3). Erectile Dysfunction. Retrieved from: https://medlineplus.gov/erectiledysfunction.html NIH. (2017). Erectile Dysfunction. Retrieved from: https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction NIH. (2016). Pulmonary arterial hypertension. Retrieved from: https://medlineplus.gov/genetics/condition/pulmonary-arterial-hypertension/ Pendick, D. (2014, June 5). Erectile dysfunction drugs and skin cancer – should you worry? Retrieved from: https://www.health.harvard.edu/blog/erectile-dysfunction-drugs-skin-cancer-worry-201406057197 Panchatsharam, P. K., & Zito, P. M. (2019, April 21). Physiology, Erection. Retrieved from: https://www.ncbi.nlm.nih.gov/books/NBK513278/ Loeb, S. et al. (2015). Use of Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction and Risk of Malignant Melanoma. Retrieved from: https://jamanetwork.com/journals/jama/fullarticle/2338254 Pottegård, A. et al. (2016). Use of sildenafil or other phosphodiesterase inhibitors and risk of melanoma. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5046205/. Wang, J. Z. et al. (2019). No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma. Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704303/
If you're taking it for erection problems you're unlikely to get side effects as you're only taking it for a short time.
Medscape: "Tobacco Education: Emphasizing Impotence as a Consequence of Smoking."
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Viagra (sildenafil citrate) is a phosphodiesterase-5 (PDE5) inhibitor used to treat impotence (or erectile disfunction, ED, the inability to attain or maintain a penile erection).
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