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Consistent with its known effects on the nitric oxide/cGMP pathway [see CLINICAL PHARMACOLOGY], VIAGRA was shown to potentiate the hypotensive effects of nitrates, and its administration to patients who are using nitric oxide donors such as organic nitrates or organic nitrites in any form either regularly and/or intermittently is therefore contraindicated.

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Erectile dysfunction (ED) becomes more common as men age. But it is not necessarily a normal part of aging. How can you avoid ED? Here's what experts told WebMD.
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The mean profiles of the change from baseline in standing systolic blood pressure in subjects treated with doxazosin in combination with 100 mg VIAGRA or matching placebo are shown in Figure 4. Effect of VIAGRA on Blood Pressure When Co-administered with Anti-hypertensives
National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC): "Erectile Dysfunction."

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For those whom sexual activity is not advised due to cardiovascular problemsPatients who are predisposed to priapism (painful erections lasting more than 4 hours)Patients with a history of non arteritic anterior ischemic optic neuropathy (NAION)Patients also taking alpha-blockers or anti-hypertensivesPatients with heart disease that require nitroglycerin pills FDA Prescribing Information Log in Get started About Medical team Health resources Log in
Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (such as heart attack or life-threatening irregular heartbeat in the past 6 months, chest pain/angina, heart failure), stroke in the past 6 months, kidney disease, liver disease, high or low blood pressure, dehydration, penis conditions (such as angulation, fibrosis/scarring, Peyronie's disease), history of painful/prolonged erection (priapism), conditions that may increase the risk of priapism (such as sickle cell anemia, leukemia, multiple myeloma), eye problems (such as retinitis pigmentosa, sudden decreased vision, NAION).

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The heavier a man is, the greater his risk for vascular disease and diabetes, which both cause ED. Obesity can also lead to the fluctuation of hormones, which can affect how the brain and body respond to sexual activity.

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Some men report an improvement in ED symptoms after having acupuncture. This ancient form of medicine involves using tiny needles to stimulate certain points on the body. While study results are mixed on whether acupuncture really works for ED, the therapy is considered safe and may help you feel better overall.

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    You could be having a serious allergic reaction and may need immediate treatment in hospital.

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    VIAGRA was administered to over 3700 patients (aged 19-87 years) during pre-marketing clinical trials worldwide. Over 550 patients were treated for longer than one year.

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    Healthy elderly volunteers (65 years or over) had a reduced clearance of sildenafil resulting in approximately 84% and 107% higher plasma AUC values of sildenafil and its active N-desmethyl metabolite, respectively, compared to those seen in healthy young volunteers (18-45 years) [see CLINICAL PHARMACOLOGY]. Due to age-differences in plasma protein binding, the corresponding increase in the AUC of free (unbound) sildenafil and its active N-desmethyl metabolite were 45% and 57%, respectively [see CLINICAL PHARMACOLOGY].

    While ED is not life threatening, the condition may result in withdrawal from sexual intimacy, reduced quality of life, decreased working productivity, and increased healthcare utilization. Patterns of care may shift away from surgical and device therapies provided by urologists and toward pharmacologic treatments and/or multidisciplinary approaches. With men increasingly seeking to preserve sexual function and quality of life as they age, the treatment of ED will take on even greater importance in the years to come.
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    The website you are about to access is not owned or controlled by VIATRIS™. Links to other websites are provided as a convenience to users and the inclusion of any link does not imply the endorsement of the linked site by Viatris. Viatris accepts no responsibility for the content of any linked sites.

    You shouldn’t use these medicines if you take nitroglycerin or any other nitrates for chest pain. If you have heart problems, tell your doctor before taking any ED medicines. These medicines can have serious side effects in people who have heart problems.
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    Testosterone is a primary male sex hormone. It is responsible for the development of male reproductive organs, secondary sexual characteristics, increased bone/muscle mass, and sexual drive (libido).

    These drugs work in response to sexual stimulation and must be taken at least half an hour to two hours before sexual activity. Drawbacks include a loss of spontaneity and cost. In addition, high-fat meals can delay the onset of action. A vacuum erection device Urethral suppositories Penile injections
    Research has shown that the same eating patterns that can cause heart attacks due to restricted blood flow in the coronary arteries can also impede blood flow to and within the penis. The blood flow is needed for the penis to become erect. Diets that include very few fruits and vegetables along with lots of fatty, fried, and processed foods can contribute to decreased blood circulation throughout the body.

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If someone collapses or isn't breathing after taking Avanafil (Stendra), call 911 Men's Diets Home Medical Reference Features Video Slideshows & Images Quizzes Expert Commentary News Archive Erectile Dysfunction Home News Reference Slideshows Quizzes Medications Find a Doctor Erectile Dysfunction Guide Overview Symptoms & Risk Factors Testing &Treatment Living & Managing Related to Erectile Dysfunction Diabetes Drug Interaction Checker Heart Disease Hypertension Living Healthy Low T Assessment Smoking Cessation

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An erection occurs because of increased blood flow to your penis. ED can occur as a problem in any stage of the erection process. It may be related to problems with blood flow to your penis, nerve damage, or stressors and emotions. Being able to achieve an erection sometimes but not every time you want to have sex Being able to achieve an erection that doesn’t last long enough for intercourse Being unable to achieve an erection at all

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Do not take avanafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking avanafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

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In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for C max and 85% for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see DOSAGE AND ADMINISTRATION and CLINICAL PHARMACOLOGY].

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