The patient's partner was also given a brief questionnaire to complete independently.
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Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. This metabolite has a PDE selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% of the parent drug. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic effects.
Methods: A facility-based cross-sectional study was conducted from March 20, 2017 to May 10, 2017, among male clients who visited community pharmacies in Gondar town, North West Ethiopia. A self-administered, structured questionnaire was used to collect data from Sildenafil users older than 18 years, that started using the drug (Sildenafil) for at least 6 months before the data collection period. A regression analysis was conducted to determine the association between study variables, and a P-value of <0.05 was considered to declare statistical significance.
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We prescribe sildenafil (generic Viagra) and tadalafil (generic Cialis). Sildenafil is prescribed in 25mg, 50mg, or 100mg doses and tadalafil is prescribed in 5mg, 10mg, and 20mg doses. Is anyone eligible to receive treatment? This service is only for men between the ages of 21 and 74Everyone has access to a free evaluation to determine if remote care to treat their ED could be a good fitThis service is available in the United States, except for Alaska, Hawaii, South Carolina, and Minnesota How much does it cost to get treated?
The cause of your erectile dysfunction might be lurking in your medicine cabinet. Several types of medication can interfere with your sexual function, and the effects might not be immediate. Antidepressants. Antihistamines. Blood-pressure medications (especially Thiazides and beta blockers). Diuretics. Chemotherapy. Parkinsons Disease treatments. Opiate painkillers. Recreational drugs like cocaine, heroin, marijuana, amphetamines and nicotine.
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Implants also make it more difficult to do surgery for an enlarged prostate, bladder cancer, or other urological conditions.
Stop taking sildenafil and contact your doctor or 111 straight away if you have a sudden decrease or loss of vision.
In addition, N-desmethyl metabolite AUC and Cmax values significantly increased by 200% and 79%, respectively in subjects with severe renal impairment compared to subjects with normal renal function.
This medication will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.
35-90% of diabetic men also experience ED. Hyperglycemia can have a negative impact on several aspects of erectile function. Complications and changes associated with diabetes can compromise macrovascular and microvascular structures, the nervous system, and blood vessel linings.
Irwin Goldstein, MD, director, sexual medicine, Alvarado Hospital, San Diego. Research funding: Pfizer. Research studies: Vivus and Medtronic.
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According to Harvard Health Publishing, some of these wellness habits can include: Losing weight Walking Performing Kegel exercises Improving vascular health Cutting out calorically dense foods Quitting smoking Reducing or eliminating alcohol intake
You should be able to achieve an erection between one and four hours after taking Viagra.
First line treatment will be medication with a phosphodiesterase inhibitor such as sildenafil (Viagra), tadalafil (Cialis) or avanafil (Spedra). These drugs only work when used together with sexual stimulation and will have no effect on your sex drive. There is no evidence that these drugs are dangerous if you have underlying heart disease. However, they should not be used if you are taking nitrates (e.g. GTN, isosorbide) for angina
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The study protocol was approved by the Ethical Review Committee of the School of Pharmacy, University of Gondar, Ethiopia with an approval number of SoP 826/09. Before the data collection, the purpose of the study and the proceedings were provided to each study participant and verbal consent was obtained. No personal identifiers were included in the questionnaire and confidentiality of the information was assured in such a way that no disclosure of the collected data was made apart from the study purpose.
PAH PDE-5 inhibitors are administered orally as tablets or suspensions, or as intravenous injections in the treatment of the following conditions: Pulmonary arterial hypertension: To improve exercise ability and slow down the progression of disease in patients with: Idiopathic PAH Inherited PAH PAH caused by connective tissue diseases Erectile dysfunction Benign prostatic hyperplasia (prostate enlargement) SLIDESHOW How to Lower Blood Pressure: Exercise Tips See Slideshow
The importance is also called as erectile dysfunction. It is a disease that affects the sexual performance of men. In this condition, it is difficult for men to have or to keep an erection required for intercourse. Libido or reduced sexual desires are the most common symptoms of erectile dysfunction.
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Ask your doctor to prescribe brand-name VIAGRA and to indicate “DAW” (Dispense As Written)—or the language used in your state—on all of your VIAGRA prescriptions.
ED doesn’t have to be a part of getting older. As a man ages, he may need more stimulation (stroking and touching) to get an erection. He might also need more time between erections. Older men should still be able to get an erection and enjoy sex. Diabetes (high blood sugar). Hypertension (high blood pressure). Atherosclerosis (hardening of the arteries). Stress, anxiety, or depression. Alcohol and tobacco use. Some prescription medicines. This includes antidepressants, pain medicine, and high blood pressure medicine. Fatigue. Brain or spinal cord injuries. Hypogonadism (a condition that leads to low levels of the male hormone, testosterone). Multiple sclerosis. Parkinson’s disease. Radiation therapy to the testicles. Stroke. Some types of prostate or bladder surgery.
Sildenafil is a weak inhibitor of the CYP isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 > 150 μM). Given sildenafil peak plasma concentrations of approximately 1 μM after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes.
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11. Levitra (Vardenafil) [Prescribing Information]. Research Triangle Park, NC: GlaxoSmithKline; November 2018.
A German study found that 69% of men involved in a sleep apnea study also suffered from ED. Disruptions to breathing during sleep affect oxygen levels in the blood, which can cause problems generating an erection. Lack of sleep also disrupts hormone production.
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Chandiramani VA, Palace J, Fowler CJ (1997) How to recognise patients with parkinsonism who should not have urological surgery. British Journal of Urology 80:100–104.
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Results: A total of 65 men participated in the study. Of the total study participants, 33.8% were aged 25–34 years and about 40% of them had multiple sexual partners. The use of sildenafil for recreational purposes was 66.2% and was found to be higher than its use for medical purposes 33.8%. Use of the drug for <1-year duration (AOR = 34.086, 95% CI [2.90, 401.37]) and 2 years duration (AOR = 21.42: 95% CI [2.10, 218.82]) were significantly associated with its use for recreational purpose. Non-recreational use of sildenafil includes erectile problems associated with diabetes mellitus (27.1%), heart disease (9.2%), hyperlipidemia (4.2%), and relationship problems due to stress and poor communication (3.1%).
If pills don't work for you or the side effects bother you severely, we can use alternative treatments. These include: injections, suppositories, vacuum devices, shockwave therapy, or surgery. ED Vacuums
Dried dates are ahighly-strengthening food and have the ability to restore sexual drive, increaseendurance and improve overall vitality, while promoting a Zen state of mind.
ED is mainly treated using oral drugs, surgery, vacuum pumps, and implants. Popular ED medication includes Viagra, Levitra and Cialis. These drugs work by increasing blood flow to the penis.
If Viagra doesn’t work for you, it may be due to a variety of factors, including the following:
Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.
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For many men, reducing smoking can help with erectile dysfunction remedy, when erectile dysfunction is the result of vascular disease, which happens when the blood supply to the penis gets restricted because of the blockage of the arteries. Smoking can also cause the narrowing of important blood vessels and can have a negative impact.
The following foods may make symptoms of impotence worse by increasing emotional stress or anxiety, raising inflammation and even causing gut trouble that interferes with nutrient absorption:
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The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice.
These drugs, which are often abused by athletes and bodybuilders, can shrink the testicles and sap their ability to make testosterone.
Erectile dysfunction is a condition that occurs mostly in men. A man cannot maintain an erect penis during sexual intercourse i.e the penis does not have the firmness required for penetration during intercourse.
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Though they rely on the same primary mechanism to treat ED, research confirms that these different PDE-5 inhibitors tend to produce side effects to various degrees. For instance, a slightly higher percentage of people who take sildenafil (and Viagra) report unwanted vision changes, while a slightly higher percentage of tadalafil (and Cialis) users report muscle pain. All in all, most men barely notice any side effects.
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Based on the pharmacokinetic profile of a single 100 mg oral dose given to healthy normal volunteers, the plasma levels of sildenafil at 24 hours post dose are approximately 2 ng/mL (compared to peak plasma levels of approximately 440 ng/mL). In the following patients: age > 65 years, hepatic impairment (e.g., cirrhosis), severe renal impairment (e.g., creatinine clearance < 30 mL/min), and concomitant use of erythromycin or strong CYP3A4 inhibitors, plasma levels of sildenafil at 24 hours post dose have been found to be 3 to 8 times higher than those seen in healthy volunteers. Although plasma levels of sildenafil at 24 hours post dose are much lower than at peak concentration, it is unknown whether nitrates can be safely co-administered at this time point [see CONTRAINDICATIONS].
More so, a study showed that Ginkgo Biloba is 84% effective in treating sexual dysfunction. The study also stated that Ginkgo Biloba, often included as ingredient in men enhancement tablets, does more than giving one an erection. In addition, the herb has a positive effect on the four phases of sexual response cycle – desire, excitement(erection and lubrication), orgasm and resolution (afterglow).
Distributed by: Pfizer Labs, Division of Pfizer Inc., NY, NY 10017. Revised: Sep 2015 SLIDESHOW Erectile Dysfunction (ED) Causes and Treatment See Slideshow Cardiovascular [see WARNINGS AND PRECAUTIONS] Prolonged Erection and Priapism [see WARNINGS AND PRECAUTIONS] Effects on the Eye [see WARNINGS AND PRECAUTIONS] Hearing Loss [see WARNINGS AND PRECAUTIONS] Hypotension when Co-administered with Alpha-blockers or Anti-hypertensives [see WARNINGS AND PRECAUTIONS] Adverse Reactions with the Concomitant Use of Ritonavir [see WARNINGS AND PRECAUTIONS] Combination with other PDE5 Inhibitors or Other Erectile Dysfunction Therapies [see WARNINGS AND PRECAUTIONS] Effects on Bleeding [see WARNINGS AND PRECAUTIONS] Counseling Patients About Sexually Transmitted Diseases [see WARNINGS AND PRECAUTIONS]
Since endothelial dysfunction, CVD and ED are closely associated in epidemiological studies, the question for clinicians is whether to recommend the man presenting with ED undergo a cardiovascular (CV) evaluation. Clearly, based on numerous studies, ED can be considered at least a ‘marker’ for possible further vascular disease or CVD.15 In their report, Vlachopoulos and coworkers make the point that the man presenting with ED, the clinician, is offered an opportunity to attempt to improve the health of the man by addressing lifestyle modification, and consider further vascular evaluation owing to the clear relationship between endothelial dysfunction, ED and CVD.19
This blog was written by Kate Taylor, a Sex Expert, Sex and Dating Features Writer, columnist and author of five books, for MyClinic.ie. How do I know if I have erectile dysfunction? How to tell if you have erectile dysfunction. There isn’t a test for erectile dysfunction you can do at home If you develop symptoms of erectile dysfunction, you need to get checked out by a doctor. I know talking to a GP abo Erectile Dysfunction FAQs Questions about ED? We’ve got you. What causes Erectile Dysfunction? Erectile dysfunction is very common in men, especially over the age of 40. The biggest causes are: Psychological problems like stress, anxiety or de Psychological impact of erectile dysfunction Understand and manage the effect that ED can have on your mental health. Erectile Dysfunction is the inability to get, or maintain, an erection long enough to have sex. It affects many men, especially as they get older. Accor MyClinic About Us Terms & Conditions Privacy policy Contact Us GP Solutions Pharmacy Solutions Blog FAQ Search for: Health Allergies Brain Health Cancer Children’s Health Diabetes Gut Health Heart Health Endocrine System Mental Health Skin & Hair Health Symptoms Treatments Weight Loss Nutrition Diets Fats & Oils Fruit Grains Hemp Herbs & Spices Mushrooms Nuts & Seeds Supplements Vegetables Vitamins & Minerals Recipes Beverages Breakfasts Main Dishes Side Dishes & Soups Salads Sauces & Dressings Snacks Desserts Recipe Search Essential Oils Beauty Body Care Cleaning Hair Care Oral Care Skin Fitness Anatomy Injury & Rehab News & Tips Running Workouts Yoga
Kegel exercises are an easy activity you can engage in to instantly begin to increase your sexual function and health. Normally used by women after giving birth, this exercise helps strengthen muscles that are responsible for holding in blood and maintaining your stamina. When not used, these muscles can become weakened and fail to help ...
When your free trial ends, you’ll find that BlueChew’s sildenafil comes in different, competitively priced prescription levels. Managing your subscription is easy. And chewable, in our opinion, is preferable to a pill you need to swallow with liquid.
Erectile dysfunction is a potential complication following prostate cancer treatments. The nerves that control an erection lie very close to the prostate and may be injured during treatment. However, some men may regain their previous level of erectile function with nerve-sparing procedures. But it may take up to a year while some men may never recover their ability to have a natural erection.
In our opinion, tadalafil beats sildenafil and vardenafil, which makes it the best choice for most men. But most importantly, scientific research leads to the same conclusion. In a meta-analysis of numerous studies, couples preferred tadalafil to sildenafil — and it wasn’t very close. In one study, nearly 80% of women preferred their sexual partners to use tadalafil, compared to sildenafil (15% preference). Therefore, the chances are pretty good that tadalafil will be best for you, too.
Other side effects associated with the use of sildenafil may include diarrhea, heartburn, difficulty falling asleep or staying asleep, numbness, burning or tingling in the arms, hands, feet or legs, nosebleeds, and sensitivity to light.
Online medicines are not always regulated and the ingredients in them can vary from one pack to another. They can cause unpleasant side effects, or may not be suitable for you.
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If you want to avoid medications, devices, or surgery, there are other, more natural ways to help erectile dysfunction.
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The trial was designed as a randomised, double blind, placebo controlled, crossover study with flexible dosage starting at 50 mg active medication or placebo and was conducted over a 24 week period in each patient. The dose could be titrated up to 100 mg or down to 25 mg depending on efficacy and tolerability. Medication was on an “as needed” basis 1 hour before sexual activity, and patients were provided with three tablets a week but advised not to take more than one each day.
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26. Tsai YS, Lin JSN, Lin YM. Safety and efficacy of alprostadil sterile powder (S. Po., CAVERJECT) in diabetic patients with erectile dysfunction. European Urology. 2000;38(2):177-183.
Natural Erectile Dysfunction Remedy, with no need for drugs regularly that may have some very serious side effects and headaches.
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Do you know about all the serious issues with Viagra and their generic substitutes? Check out how a lot of informed men are able to regain full function without pills, shots, or surgery and go back to being intimate the natural way.
