Sildenafil is cleared predominantly by the CYP3A4 (major route) and CYP2C9 (minor route) hepatic microsomal isoenzymes. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. This metabolite has a PDE selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% of the parent drug. Plasma concentrations of this metabolite are approximately 40% of those seen for sildenafil, so that the metabolite accounts for about 20% of sildenafil's pharmacologic effects.
Methods: A facility-based cross-sectional study was conducted from March 20, 2017 to May 10, 2017, among male clients who visited community pharmacies in Gondar town, North West Ethiopia. A self-administered, structured questionnaire was used to collect data from Sildenafil users older than 18 years, that started using the drug (Sildenafil) for at least 6 months before the data collection period. A regression analysis was conducted to determine the association between study variables, and a P-value of <0.05 was considered to declare statistical significance. .
We prescribe sildenafil (generic Viagra) and tadalafil (generic Cialis). Sildenafil is prescribed in 25mg, 50mg, or 100mg doses and tadalafil is prescribed in 5mg, 10mg, and 20mg doses. Is anyone eligible to receive treatment? This service is only for men between the ages of 21 and 74Everyone has access to a free evaluation to determine if remote care to treat their ED could be a good fitThis service is available in the United States, except for Alaska, Hawaii, South Carolina, and Minnesota How much does it cost to get treated?
The cause of your erectile dysfunction might be lurking in your medicine cabinet. Several types of medication can interfere with your sexual function, and the effects might not be immediate. Antidepressants. Antihistamines. Blood-pressure medications (especially Thiazides and beta blockers). Diuretics. Chemotherapy. Parkinsons Disease treatments. Opiate painkillers. Recreational drugs like cocaine, heroin, marijuana, amphetamines and nicotine.
Implants also make it more difficult to do surgery for an enlarged prostate, bladder cancer, or other urological conditions.
Stop taking sildenafil and contact your doctor or 111 straight away if you have a sudden decrease or loss of vision.
35-90% of diabetic men also experience ED. Hyperglycemia can have a negative impact on several aspects of erectile function. Complications and changes associated with diabetes can compromise macrovascular and microvascular structures, the nervous system, and blood vessel linings.
Irwin Goldstein, MD, director, sexual medicine, Alvarado Hospital, San Diego. Research funding: Pfizer. Research studies: Vivus and Medtronic.
You should be able to achieve an erection between one and four hours after taking Viagra.
First line treatment will be medication with a phosphodiesterase inhibitor such as sildenafil (Viagra), tadalafil (Cialis) or avanafil (Spedra). These drugs only work when used together with sexual stimulation and will have no effect on your sex drive. There is no evidence that these drugs are dangerous if you have underlying heart disease. However, they should not be used if you are taking nitrates (e.g. GTN, isosorbide) for angina
PAH PDE-5 inhibitors are administered orally as tablets or suspensions, or as intravenous injections in the treatment of the following conditions: Pulmonary arterial hypertension: To improve exercise ability and slow down the progression of disease in patients with: Idiopathic PAH Inherited PAH PAH caused by connective tissue diseases Erectile dysfunction Benign prostatic hyperplasia (prostate enlargement) SLIDESHOW How to Lower Blood Pressure: Exercise Tips See Slideshow
The importance is also called as erectile dysfunction. It is a disease that affects the sexual performance of men. In this condition, it is difficult for men to have or to keep an erection required for intercourse. Libido or reduced sexual desires are the most common symptoms of erectile dysfunction.
ED doesn’t have to be a part of getting older. As a man ages, he may need more stimulation (stroking and touching) to get an erection. He might also need more time between erections. Older men should still be able to get an erection and enjoy sex. Diabetes (high blood sugar). Hypertension (high blood pressure). Atherosclerosis (hardening of the arteries). Stress, anxiety, or depression. Alcohol and tobacco use. Some prescription medicines. This includes antidepressants, pain medicine, and high blood pressure medicine. Fatigue. Brain or spinal cord injuries. Hypogonadism (a condition that leads to low levels of the male hormone, testosterone). Multiple sclerosis. Parkinson’s disease. Radiation therapy to the testicles. Stroke. Some types of prostate or bladder surgery.
Sildenafil is a weak inhibitor of the CYP isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 > 150 μM). Given sildenafil peak plasma concentrations of approximately 1 μM after recommended doses, it is unlikely that VIAGRA will alter the clearance of substrates of these isoenzymes.
11. Levitra (Vardenafil) [Prescribing Information]. Research Triangle Park, NC: GlaxoSmithKline; November 2018.
Respiratory: asthma, dyspnea, laryngitis, pharyngitis, sinusitis, bronchitis, sputum increased, cough increased.
A German study found that 69% of men involved in a sleep apnea study also suffered from ED. Disruptions to breathing during sleep affect oxygen levels in the blood, which can cause problems generating an erection. Lack of sleep also disrupts hormone production.