After either oral or intravenous administration, sildenafil is excreted as metabolites predominantly in the feces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose). Similar values for pharmacokinetic parameters were seen in normal volunteers and in the patient population, using a population pharmacokinetic approach.
Men who have ED should not ignore the ailment. After all, more than 40 percent of men over the age of 40 struggle with ED. Men struggling with ED should talk to their doctor about potential causes and treatment options, as well as make lifestyle changes to reduce incidence. Young men should take preventive steps, including the development of healthy lifestyle habits, like eating a balanced diet and maintaining a healthy weight, which can reduce their risk of ED.
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Following foods have the potential to cure erectile dysfunction as pill, pumps, or surgeries can do.
They work for most men and can be used if medicine is not suitable or does not work.
Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, sildenafil works by increasing blood flow to the penis to help a man get and keep an erection.This drug does not protect against sexually transmitted diseases (such as HIV, hepatitis B, gonorrhea, syphilis). Practice "safe sex" such as using latex condoms. Consult your doctor or pharmacist for more details.
A 2011 survey on recreational use of ED medications published in the journal Archives of Sexual Behavior included responses from 1,994 men attending 497 colleges across the country. Four percent of these men admitted to using ED drugs recreationally. A majority of the recreational users mixed ED drugs with illegal drugs and engaged in risky sexual behaviors. Recreational use was associated with substance abuse and a higher number of sex partners.
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If you use any of these medications and start to have erection problems, don't just stop taking them on your own. Talk to your doctor about possible fixes.
In many situations, identifying an underlying minor physical problem relieves the anxiety component of erectile dysfunction, and many patients see improvement without further intervention.
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An erection occurs because of increased blood flow to your penis. ED can occur as a problem in any stage of the erection process. It may be related to problems with blood flow to your penis, nerve damage, or stressors and emotions. Being able to achieve an erection sometimes but not every time you want to have sex Being able to achieve an erection that doesn’t last long enough for intercourse Being unable to achieve an erection at all
Sildenafil was not carcinogenic when administered to rats for 24 months at a dose resulting in total systemic drug exposure (AUCs) for unbound sildenafil and its major metabolite of 29-and 42-times, for male and female rats, respectively, the exposures observed in human males given the Maximum Recommended Human Dose (MRHD) of 100 mg. Sildenafil was not carcinogenic when administered to mice for 18-21 months at dosages up to the Maximum Tolerated Dose (MTD) of 10 mg/kg/day, approximately 0.6 times the MRHD on a mg/m² basis.
In this study, ED proceeded CVD in almost 70% of cases. Similarly, many men with ED have been found to have pre-existing CVD. A study by Vlachopoulos et al evaluated the incidence of asymptomatic CVD in 50 men with ED.22 These authors found that 19% of men with ED had asymptomatic CVD. Similarly, Mulhall and colleagues found that 20% of men presenting with ED and vascular insufficiency on penile duplex had asymptomatic CVD.23
The occasional inability to achieve a satisfactory erection doesn't normally constitute a problem. What's the risk? Most men will experience an erection problem at least once. This could be due to stress, exhaustion, too much alcohol or simply not feeling like sex. Persistent erectile dysfunction (ED) is estimated to affect about 10% of men at any one time. Although age itself isn't a cause of erectile dysfunction (ED), the risk nevertheless increases as you get older: 18% of 50—59 year olds have trouble with their erections compared with 7% of 18—29 year olds. What causes it?
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The prescription medication Viagra (sildenafil) for erectile dysfunction is generally safe for otherwise healthy men.
Do not take sildenafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.
I F Hussaina, C M Bradya, M J Swinna, C J Mathiasb, C J Fowlera aUro-Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK, bAutonomic Unit, National Hospital for Neurology and Neurosurgery Dr C J Fowlerc.fowler{at}ion.ucl.ac.uk